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IF=52.7 Xu Y, Zheng Y, Liu Y,et al. Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection[J]. Signal Transduction andTargeted Therapy, 2025, 10(1): 1-13.

IF=52.7 Ma B, Ju A, Zhang S,et al. Albumosomes formed by cytoplasmic pre-folding albumin maintainmitochondrial homeostasis and inhibit nonalcoholic fatty liver disease[J].Signal Transduction and Targeted Therapy, 2023, 8(1): 229.

IF=42.5 Chen Y, Chen S, Liu Z,et al. Red blood cells undergo lytic programmed cell death involving NLRP3[J].Cell, 2025, 188(11): 3013-3029. e19.

IF=33.9 Zheng Z, Zeng X, ZhuY, et al. CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis[J]. Molecular Cancer, 2024, 23(1): 4.

IF=30.9 Li C, Lu Y, Li Y, et al. Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression[J]. Cell Metabolism, 2025.

IF=23.2 Ma P, Guo J, Peng L, et al. PD-1-engineered manganese-based nanoplatform loaded with CXCL9 induces ICD and intensifies T-cell infiltration for melanoma treatment[J]. Advanced Composites and Hybrid Materials, 2025, 8(3): 242.

IF=21.7 Zeng X, Chen Z, Zhu Y,et al. O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictatessensitivity to sunitinib in renal cell carcinoma[J]. Drug Resistance Updates,2024, 77: 101150.

IF=20.6 Wang J, Zheng A, LiuN, et al. Integrative spatial multiomics analysis reveals regulatory mechanismsof VCAM1+ proximal tubule cells in lupus nephritis[J]. Annals of the Rheumatic Diseases, 2025.

IF=20.3 Sun J, Yang F, Wang L,et al. Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS andenhances efficiency of mesenchymal stem cell therapy in intervertebral discdegeneration[J]. Bioactive Materials, 2023, 23: 247-260.

IF=20.3 Wei X, Wang L, Duan C,et al. Cardiac patches made of brown adipose-derived stem cell sheets andconductive electrospun nanofibers restore infarcted heart for ischemicmyocardial infarction[J]. Bioactive Materials, 2023, 27: 271-287.

IF=20.3 Ma C, Qi X, Wei Y F,et al. Amelioration of ligamentum flavum hypertrophy using umbilical cordmesenchymal stromal cell-derived extracellular vesicles[J]. Bioactive Materials, 2023, 19: 139-154.

IF=20.3 Wang Z, Sha T, Li J,et al. Turning foes to friends: Advanced “in situ nanovaccine” with dualimmunoregulation for enhanced immunotherapy of metastatic triple-negativebreast cancer[J]. Bioactive Materials, 2024, 39: 612-629.

IF=20.3 Li X, Liang X, Fu W,et al. Reversing cancer immunoediting phases with a tumor-activated andoptically reinforced immunoscaffold[J]. Bioactive Materials, 2024, 35: 228-241.

IF=19.5 Chen C Y, Wang Z, Hong C G, et al. Brain neuron-derived WDFY1 induces bone loss[J]. Nature Aging, 2026: 1-20.

IF=19 Zhang L, Wu Z, Zhao X, et al. An Ultrafast Self‐Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine[J]. Advanced Functional Materials, 2025: e25541.

IF=19 Lu Q, Chen R, Zeng F,et al. Inhalation of Bioorthogonal Gene‐Editable Spiky‐Pollen Reprograms Tumor‐Associated Macrophages for Lung Cancer Immunotherapy[J]. Advanced Functional Materials, 2024: 2408767.

IF=16.6 Gao Y, Zhu Y, Wang H,et al. Lipid-mediated phase separation of AGO proteins on the ER controlsnascent-peptide ubiquitination[J]. Molecular Cell, 2022, 82(7): 1313-1328. e8.

IF=16 Yang X, Fan Y, LiangJ, et al. Polyaptamer-driven crystallization of alendronate for synergisticosteoporosis treatment through osteoclastic inhibition and osteogenicpromotion[J]. ACS nano, 2024, 18(33): 22431-22443.

IF=16 Deng W, Wang Y, WangJ, et al. Leveraging Vitamin C to Augment Nanoenabled Photothermal Immunotherapy[J]. ACS nano, 2025, 19(13): 12982-12995.

IF=16 Lu Q, Ye C, Mao W, etal. Targeting Senescent Alveolar Type 2 Cells with a Gene-Editable FePtDual-Atom Catalyst for Mitigating Idiopathic Pulmonary Fibrosis[J]. ACS nano,2025.

IF=15.7 Zhou H, Xiao Y, Xue X, et al. Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation[J]. Nature Communications, 2025.

IF=15.7 Ma B, Yao Y, Dong H, et al. Atomic structure and in situ visualization of native PMEL lamellae in melanosomes[J]. Nature Communications, 2025, 16(1): 10300.

IF=15.7 Jin H, Zhu X, Zhang M, et al. Cu/Zn/histidine supramolecular assemblies with optimized Cu catalytic sites as an alternative of superoxide dismutase[J]. Nature Communications, 2025, 16(1): 10075.

IF=15.7 Bu J, Zhang Y, Wu S,et al. KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triplenegative breast cancer[J]. Nature Communications, 2023, 14(1): 2602.

IF=15.7 Tong F, Wang Y, Xu Y,et al. MMP-2-triggered, mitochondria-targeted PROTAC-PDT therapy of breast cancer and brain metastases inhibition[J]. Nature Communications, 2024, 15(1):10382.

IF=15.7 Yang Y, Zhao X, WangS, et al. Ultra-durable cell-free bioactive hydrogel with fast shape memory andon-demand drug release for cartilage regeneration[J]. Nature Communications,2023, 14(1): 7771.

IF=15.4 Mei Q, Zhang Y, Li H,et al. Hepatic factor MANF drives hepatocytes reprogramming by detainingcytosolic CK19 in intrahepatic cholangiocarcinoma[J]. Cell Death & Differentiation, 2025: 1-19.

IF=15.4 Yu X, Feng M, Guo J,et al. MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy[J]. Cell Death & Differentiation, 2024: 1-14.

IF=14.7 Ma J, Zhao J, Zhang C,et al. Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy[J]. Nature Communications, 2025, 16(1): 5006.

IF=14.7 Liang J, Wan Y, Gao J,et al. Erythroid-intrinsic activation of TLR8 impairs erythropoiesis ininherited anemia[J]. Nature Communications, 2024, 15(1): 1-17.

IF=14.6 Tan Z, Liu Y, Li X, et al. Bladder adaptive hydrogel scaffold with dual release, antimicrobial, immunomodulatory, and repair: DRIVER for urinary tract infections[J]. Acta Pharmaceutica Sinica B, 2026.

IF=14.6 Fan H, Zhao M, Jiang H, et al. Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma[J]. Acta Pharmaceutica Sinica B, 2024, 14(6): 2748-2760.

IF=14.1 Kong X, Gu H, Zhang Y, et al. β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration[J]. Advanced Science, e05077.

IF=14.1 Zhang Y, Yao S, Zhao Y, et al. STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer[J]. Advanced Science, 2025: e20547.

IF=14.1 Ning Y Q, Wang J, Zhang Y, et al. Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma[J]. Advanced Science, 2025: e09344.

IF=14.1 Zhou L H, Gu L F, Chen Y X, et al. HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming[J].Advanced Science, 2025: e05820.

IF=14.1 Jia S, Liu W, Zhang M,et al. Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes andImpairs Fracture Healing Through ApoE‐Induced Senescence[J]. Advanced Science, 2024, 11(46): 2400502.

IF=14.1 Wei Y S, Tang W J, MaoP Y, et al. Sexually Dimorphic Response to Hepatic Injury in Newborn Sufferingfrom Intrauterine Growth Restriction[J]. Advanced Science, 2024: 2403095.

IF=14.1 Hu C, Zheng Z, Pang S,et al. Chimeric SFT2D2‐TBX19 Promotes Prostate Cancer Progression by Encoding TBX19‐202 Protein and StabilizingMitochondrial ATP Synthase through ATP5F1A Phosphorylation[J]. Advanced Science, 2024, 11(48): 2408426.

IF=14.1 Fu J, Wu S, Bao N, etal. A Universal Strategy of Anti‐Tumor mRNA Vaccine by Harnessing “Off‐the‐Shelf” Immunity[J]. Advanced Science, 2025, 12(8): 2401287.

IF=13.3 Chen R, Xie C, Ning Z, et al. Pathogenomic analysis reveals clinically relevant epithelial-mesenchymal plasticity in esophageal squamous cell carcinoma[J]. Theranostics, 2026, 16(7): 3870.

IF=13.3 Ji B, Guo H, Xing R, et al. Nanobody Nb07 mitigates sepsis by blocking the PFKM-p53-PD-1 axis to enhance macrophage phagocytosis[J]. Theranostics, 2026, 16(7): 3408.

IF=13.3 Liu B, Hua D, Shen L,et al. NPC1 is required for postnatal islet β cell differentiation by maintaining mitochondria turnover[J]. Theranostics, 2024, 14(5): 2058.

IF=13.3 Sun Y, Liu Q, Qin Y,et al. Exosomes derived from CD271+ CD56+ bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury[J]. Theranostics, 2024, 14(2): 510.

IF=13.1 Cao X, Zheng J, ZhangR, et al. Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@ DNA probe[J]. Nucleic Acids Research, 2024: gkae202.

IF=13 Zhang Y, Chen C, Udenigwe C C, et al. Tetrapeptides derived from black bean enhance osteogenesis and alleviate ovariectomy-induced bone loss via activation of BMP-2/Smad signaling[J]. Journal of Advanced Research, 2026.

IF=12.9 Yang H H, Jiang H L,Tao J H, et al. Mitochondrial citrate accumulation drives alveolar epithelialcell necroptosis in lipopolysaccharide-induced acute lung injury[J]. Experimental & Molecular Medicine, 2022, 54(11): 2077-2091.

IF=12.9 Zhu L, Tang Z, JiangW, et al. Cholesterol biosynthesis induced by radiotherapy inhibits cGAS–STING activation and contributes to colorectal cancer treatment resistance[J]. Experimental & Molecular Medicine, 2025: 1-17.

IF=12.8 Shan J, Li X, Sun R,et al. Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPARγ-driven lipid biosynthesis via regulating lipidome metabolic reprogramming[J]. Journal of Experimental & Clinical Cancer Research, 2024,43(1): 227.

IF=12.6 Guo Z, Wu L, Niu Y, et al. Triple-targeting miRNA-loaded core-shell nanoparticles in injectable hydrogel enable coordinated diabetic wound repair[J]. Journal of Nanobiotechnology, 2025, 23: 764.

IF=12.6 Lv Q, Wang Y, Tian W,et al. Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis[J]. Journal of Nanobiotechnology,2023, 21(1): 419.

IF=12.6 Chen Y, Wu Y, Guo L,et al. Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration byregulating macrophage polarization via DDX3X/NLRP3 axis[J]. Journal of Nanobiotechnology, 2023, 21(1): 98.

IF=12.6 Cao H, Li W, Zhang H,et al. Bio-nanoparticles loaded with synovial-derived exosomes ameliorateosteoarthritis progression by modifying the oxidative microenvironment[J]. Journal of Nanobiotechnology, 2024, 22(1): 271.

IF=12.5 Li Z, Feng L, Wei X, et al. IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration[J]. Cell Discovery, 2026, 12(1): 5.

IF=12.5 Liu B, Duan X, Wang G, et al. Crotonate suppresses breast cancer metastasis and promotes immunotherapy response by inducing ACSS2-mediated EZH2-K348 crotonylation[J]. Science Advances, 2026, 12(3): eaea9892.

IF=12.5 Yang Z, Liu H, Li S,et al. Temporally programmed STING nanoadjuvant delivery unlocks synergisticchemotherapy-induced antitumor immunity[J]. Science Advances, 2025, 11(29):eadw0797.

IF=12.5 Wu D, Wang X, Li R, etal. Femtosecond laser–assisted printing of hard magnetic microrobots forswimming upstream in subcentimeter-per-second blood flow[J]. Science Advances,2025, 11(27): eadw1272.

IF=12.5 Teng J, Zhao W, ZhangS, et al. Injectable nanoparticle-crosslinked xyloglucan/ε-poly-l-lysinecomposite hydrogel with hemostatic, antimicrobial, and angiogenic propertiesfor infected wound healing[J]. Carbohydrate Polymers, 2024: 122102.

IF=12.2 Li T, Wang H, Jiang Y,et al. LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling[J]. International Journal of Oral Science, 2023, 15(1): 33.

IF=12.1 Jiang B, Peng C, Li X,et al. Banana starch nanoparticles disrupt the integrity of the intestinal barrier by opening tight junctions in mice[J]. Small, 2025, 21(5): 2408298.

IF=11.5 Liu Y, Li J, Guo R, et al. Bioinspired nanomicelles with octopus-like adhesion for microenvironmental reprogramming in periodontitis[J]. Journal of Controlled Release, 2026: 114649.

IF=11.5 Liang Q, Peng Y, Zhao L, et al. Pulmonary macrophage-targeted RNAi and mRNA co-delivery via SORT lipid nanoparticles enhances immunotherapy in lung cancer[J]. Journal of Controlled Release, 2025: 114519.

IF=11.5 Sun Y, Zhao J, Liu Q,et al. Intranasal delivery of small extracellular vesicles from specific subpopulation of mesenchymal stem cells mitigates traumatic spinal cord injury[J]. Journal of Controlled Release, 2024, 369: 335-350.

IF=10.6 Sun X, Cai X, Li S, etal. High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy[J]. Cell Reports Medicine, 2025.

IF=10.6 Huang H, Liu S, Xu L,et al. Translational selenium nanomedicine synergizes with nab-paclitaxel to enhance antitumor effects in esophageal squamous cell cancer via selenoprotein N-mediated ER stress[J]. Journal of Nanobiotechnology, 2025, 23(1): 294.

IF=10.5 Hong W, Zeng X, Wang H, et al. PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis[J]. Pharmacological Research, 2024: 107228.

IF=10.2 Liao Z, Zhang L, Wu Z, et al. E0703 targets ERβ to facilitate the upregulation of GLI3, thereby alleviating irradiation-induced DNA damage on lymphocytes[J]. Cellular & Molecular Biology Letters, 2025, 30(1): 136.

IF=10.1 Tan S, Chen Y, Chen Y, et al. HOXC8-activated TRIM22/NF-κB Pathway Promotes Stemness in Colorectal Cancer[J]. Cancer Letters, 2025: 218156.

IF=10.1 Li W, Ali T, Zheng C,et al. Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes[J]. Molecular Psychiatry, 2022,27(2): 1047-1058.

IF=10 Bai J, Si G, Wang R, et al. Gut Metabolite Indoleacrylic Acid Suppresses Osteoclast Formation by AHR mediated NF-κB Signaling Pathway[J]. International Journal of Biological Sciences, 2026, 22(2): 951.

IF=10 Zhong S, Guo Q, Chen X, et al. The inhibition of YTHDF3/m6A/LRP6 reprograms fatty acid metabolismand suppresses lymph node metastasis in cervical cancer[J]. InternationalJournal of Biological Sciences, 2024, 20(3): 916.